Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 18/20 | 0.52 |
| ▸ | F2 | P00734 | 3/20 | 0.52 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872417 | 0.92 | CCNA2 (0.52) | CCNA2CDK2CCNA1GAAF10 | |
| SCHEMBL1996121 | 0.90 | CCNA2 (0.49) | CCNA2CDK2CCNA1GAAF10 | |
| SCHEMBL3885099 | 0.90 | F10 (0.62) | F10F2SLC29A1 | |
| SCHEMBL1996263 | 0.89 | F10 (0.69) | CCNA2CDK2CCNA1GAAF10 | |
| SCHEMBL3873568 | 0.89 | F10 (0.69) | F10F2SLC29A1 | |
| SCHEMBL15628309 | 0.86 | F10 (0.51) | CCNA2CDK2CCNA1F10F2 | |
| SCHEMBL15628284 | 0.86 | F10 (0.54) | CCNA2CDK2CCNA1F10F2 | |
| SCHEMBL15628280 | 0.85 | CCNA2 (0.47) | CCNA2CDK2CCNA1GAAF10 | |
| SCHEMBL18028067 | 0.84 | F10 (0.68) | F10F2SLC29A1 | |
| SCHEMBL5311034 | 0.83 | ALDH1A1 (0.58) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579472-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-25 | — | — | US | disclosed |
| US-7435821-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435821-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435821-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | MUDRYK BOGUSLAW M | 2008-01-10 | — | — | US | disclosed |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | MUDRYK BOGUSLAW M | 2008-01-10 | — | — | US | disclosed |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | MUDRYK BOGUSLAW M | 2008-01-10 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | MUDRYK BOGUSLAW M | 2007-12-06 | — | — | US | disclosed |
| US-7304157-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304157-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304157-B2 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070282106-A1 | EFFICIENT SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-c]PYRID-2-ONES | F2, TFPI, PDXK | CCNA2 1358/4885CDK2 159/4885CCNA1 2425/4885 |
| US-20060069119-A1 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | F2, TFPI, PDXK | CCNA2 1358/4885CDK2 159/4885CCNA1 2425/4885 |
| US-20080009626-A1 | Reacting a 3-leaving group-1-(p-leaving group-phenyl)tetrahydro-2-pyridone with 2-hydroxypyridine and reacting the product with an alpha-oxoacetaldehyde phenylhydrazone to form 1-phenyl-3-carbonyl-6-(p-(2-pyridon-1-yl)phenyl-4,5-dihydro-pyrazolo[3,4-c]pyrid-2-one derivatives; bases; aprotic solvents | PDXK, PLPBP, PNPO | CCNA2 2365/4885CDK2 520/4885CCNA1 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.