Sugi Predict

Sugi Predict / Compounds / SCHEMBL387950

SCHEMBL387950

SCHEMBL387950

CC(C)(C)OC(=O)NC(CNS(C)(=O)=O)c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PPARA Q07869 2/20 0.42
▸ PPARG P37231 1/20 0.42
▸ ROCK2 O75116 1/20 0.42
▸ AKT1 P31749 1/20 0.42
▸ P2RY2 P41231 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ TRPA1 O75762 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ GRIA4 P48058 1/20 0.40
▸ HDAC6 Q9UBN7 2/20 0.39
▸ CACNA1B Q00975 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ S1PR3 Q99500 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ CTSK P43235 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL390933 0.88 P2RY2 (0.44) PPARAPPARGROCK2AKT1P2RY2
SCHEMBL391352 0.82 PPARG (0.42) PPARAPPARGP2RY2ALDH1A1MAPT
SCHEMBL393273 0.82 PPARG (0.43) PPARAPPARGP2RY2ALDH1A1MAPT
SCHEMBL390923 0.82 GAA (0.44) PPARAPPARGROCK2AKT1P2RY2
SCHEMBL391406 0.82 PPARG (0.43) PPARAPPARGROCK2AKT1P2RY2
SCHEMBL14847725 0.81 GAA (0.48) PPARAPPARGP2RY2ALDH1A1MAPT
SCHEMBL393133 0.81 GAA (0.48) PPARAPPARGP2RY2ALDH1A1MAPT
SCHEMBL20544744 0.81 ROCK2 (0.46) ROCK2AKT1MAPTGAAGRIA4
SCHEMBL391356 0.81 P2RY2 (0.42) PPARAPPARGP2RY2ALDH1A1MAPT
SCHEMBL389645 0.81 P2RY2 (0.42) PPARAPPARGP2RY2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2015-07-02 — — US disclosed
CN-101861321-B Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors ASTRAZENECA AB 2013-02-06 — — CN disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
CN-101861321-A Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors ASTRAZENECA AB 2010-10-13 — — CN disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
WO-2009047563-A1 PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2009-04-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885
US-20220220116-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 PPARA 3942/4885PPARG 3172/4885ROCK2 85/4885
US-20200239483-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 PPARA 3942/4885PPARG 3172/4885ROCK2 85/4885
US-11236095-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 PPARA 3942/4885PPARG 3172/4885ROCK2 85/4885
US-11760760-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 PPARA 4173/4885PPARG 3405/4885ROCK2 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.