Sugi Predict

Sugi Predict / Compounds / SCHEMBL390933

SCHEMBL390933

SCHEMBL390933

CC(C)(C)OC(=O)NC(CCNS(C)(=O)=O)c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ P2RY2 P41231 1/20 0.44
▸ ROCK2 O75116 1/20 0.43
▸ AKT1 P31749 1/20 0.43
▸ AKT2 P31751 1/20 0.43
▸ KCNH2 Q12809 1/20 0.43
▸ AKT3 Q9Y243 1/20 0.43
▸ PPARG P37231 1/20 0.40
▸ PPARA Q07869 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ MAPT P10636 1/20 0.40
▸ UTS2R Q9UKP6 9/20 0.39
▸ TRPA1 O75762 1/20 0.39
▸ GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL387950 0.88 PPARA (0.42) P2RY2ROCK2AKT1PPARGPPARA
SCHEMBL391098 0.85 P2RY2 (0.47) P2RY2AKT1PPARGPPARAALDH1A1
SCHEMBL389645 0.83 P2RY2 (0.42) P2RY2PPARGPPARAALDH1A1MAPT
SCHEMBL391356 0.83 P2RY2 (0.42) P2RY2PPARGPPARAALDH1A1MAPT
SCHEMBL390470 0.83 P2RY2 (0.46) P2RY2AKT1PPARGPPARAALDH1A1
SCHEMBL390753 0.82 P2RY2 (0.46) P2RY2PPARGPPARAALDH1A1MAPT
SCHEMBL17603813 0.82 P2RY2 (0.46) P2RY2PPARGPPARAALDH1A1MAPT
SCHEMBL391157 0.82 P2RY2 (0.46) P2RY2PPARGPPARAALDH1A1MAPT
SCHEMBL20544740 0.82 ROCK2 (0.47) ROCK2AKT1AKT2KCNH2AKT3
SCHEMBL392960 0.82 CA2 (0.43) P2RY2ROCK2AKT1PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
CN-101861321-A Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors ASTRAZENECA AB 2010-10-13 — — CN disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
WO-2009047563-A1 PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2009-04-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885
US-20220220116-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 P2RY2 1335/4885ROCK2 85/4885AKT1 4/4885
US-20200239483-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 P2RY2 1335/4885ROCK2 85/4885AKT1 4/4885
US-11236095-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885
US-11760760-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 P2RY2 1136/4885ROCK2 60/4885AKT1 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.