Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 9/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880595 | 0.85 | HDAC6 (0.39) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3878461 | 0.83 | RBP4 (0.44) | RBP4CYP3A4CYP2C9CYP2C19SLC9A1 | |
| SCHEMBL3879091 | 0.82 | UBE2M (0.41) | CYP3A4CYP2C9CYP2C19SLC9A1UBE2M | |
| SCHEMBL3881507 | 0.82 | GRM5 (0.35) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3878476 | 0.82 | RBP4 (0.43) | RBP4PIK3CDPIK3CAUBE2MDCUN1D1 | |
| SCHEMBL3879404 | 0.81 | UBE2M (0.39) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3884855 | 0.81 | GRM5 (0.32) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3882385 | 0.81 | UBE2M (0.43) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3880547 | 0.81 | UBE2M (0.34) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3885757 | 0.81 | GRM5 (0.37) | UBE2MDCUN1D1LMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | GLAXO GROUP LIMITED | 2008-07-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | HRH3, HRH4, HRH2 | RBP4 3396/4885CYP3A4 2320/4885CYP2C9 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.