Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | UBE2M | P61081 | 3/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880590 | 0.85 | HSD11B1 (0.41) | CYP3A4CYP2C9CYP2C19UBE2MDCUN1D1 | |
| SCHEMBL3880911 | 0.83 | RBP4 (0.43) | RBP4CYP3A4CYP2C9CYP2C19SLC9A1 | |
| SCHEMBL3879089 | 0.81 | KDM4E (0.51) | CYP3A4CYP2C9CYP2C19L3MBTL3L3MBTL1 | |
| SCHEMBL3878472 | 0.81 | RBP4 (0.44) | RBP4L3MBTL3L3MBTL1PIK3CDPIK3CA | |
| SCHEMBL3881503 | 0.81 | L3MBTL3 (0.37) | L3MBTL3L3MBTL1UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL3879400 | 0.81 | L3MBTL3 (0.40) | CYP3A4CYP2C9CYP2C19L3MBTL3L3MBTL1 | |
| SCHEMBL3882382 | 0.80 | L3MBTL3 (0.44) | CYP3A4CYP2C9CYP2C19L3MBTL3L3MBTL1 | |
| SCHEMBL3880543 | 0.80 | MGLL (0.35) | CYP3A4CYP2C9CYP2C19L3MBTL3L3MBTL1 | |
| SCHEMBL3885754 | 0.80 | POLB (0.41) | L3MBTL3L3MBTL1UBE2MDCUN1D1ALDH1A1 | |
| SCHEMBL3879360 | 0.80 | UBE2M (0.55) | CYP3A4CYP2C9CYP2C19L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | GLAXO GROUP LIMITED | 2008-07-03 | — | — | US | claimed |
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161289-A1 | Fused Thiazole Derivatives Having Affinity for the Histamine H3 Receptor | HRH3, HRH4, HRH2 | RBP4 3396/4885CYP3A4 2320/4885CYP2C9 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.