Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KAT7 | O95251 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859029 | 1.00 | GAA (0.46) | GAARAB9APOLBKAT7KAT8 | |
| SCHEMBL1860261 | 0.91 | POLB (0.52) | GAARAB9APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL1860263 | 0.91 | POLB (0.52) | GAARAB9APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL12991579 | 0.85 | ALDH1A1 (0.51) | GAARAB9APOLBL3MBTL1ALDH1A1 | |
| SCHEMBL3617205 | 0.84 | GAA (0.49) | GAARAB9APOLBALDH1A1MAPT | |
| SCHEMBL1867619 | 0.84 | GAA (0.49) | GAARAB9APOLBALDH1A1MAPT | |
| SCHEMBL970360 | 0.83 | POLB (0.51) | GAARAB9APOLBALDH1A1MAPT | |
| SCHEMBL970359 | 0.83 | POLB (0.51) | GAARAB9APOLBALDH1A1MAPT | |
| SCHEMBL5593571 | 0.82 | RAB9A (0.53) | GAARAB9APOLBKAT7KAT8 | |
| SCHEMBL1861675 | 0.82 | RAB9A (0.53) | GAARAB9APOLBKAT7KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |