Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3000853 | 0.99 | HSD11B1 (0.42) | HSD11B1NPC1RAB9ASMN1; SMN2BCL2L1 | |
| SCHEMBL209242 | 0.92 | HSD11B1 (0.43) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL2999252 | 0.87 | HSD11B1 (0.50) | HSD11B1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2994511 | 0.87 | HSD11B1 (0.44) | HSD11B1SMN1; SMN2BCL2L1MCL1MEN1 | |
| SCHEMBL13266359 | 0.86 | HSD11B1 (0.44) | HSD11B1SMN1; SMN2BCL2L1MCL1KMT2A | |
| SCHEMBL3882100 | 0.85 | ERN1 (0.41) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL3000850 | 0.84 | ERN1 (0.41) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL208632 | 0.82 | HSD11B1 (0.43) | HSD11B1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL3554331 | 0.82 | HSD11B1 (0.60) | HSD11B1CNR1 | |
| SCHEMBL3880954 | 0.82 | PDE5A (0.47) | HSD11B1NPC1RAB9ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | claimed |
| US-20080275043-A1 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 | ELI LILLY AND COMPANY | 2008-11-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275043-A1 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSDL2, HSD17B1 | HSD11B1 1/4885NPC1 1034/4885RAB9A 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.