Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261952 | 0.87 | MAPT (0.54) | ALDH1A1SMN1; SMN2HPGDCA12CA1 | |
| SCHEMBL14894911 | 0.87 | POLB (0.57) | ALDH1A1L3MBTL1SMN1; SMN2HPGDCA12 | |
| SCHEMBL3193640 | 0.86 | ALDH1A1 (0.67) | HRH4ALDH1A1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL12261938 | 0.85 | ALDH1A1 (0.46) | HRH4ALDH1A1SMN1; SMN2HPGDCA12 | |
| SCHEMBL12260740 | 0.83 | KMT2A (0.60) | ERN1ALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL12261931 | 0.83 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1SMN1; SMN2HPGDCA12 | |
| SCHEMBL521638 | 0.83 | HRH4 (0.53) | HRH4ALDH1A1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL12260742 | 0.81 | SMN1; SMN2 (0.59) | ALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL12261942 | 0.80 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL12261934 | 0.80 | L3MBTL1 (0.59) | ALDH1A1L3MBTL1SMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357909-B1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20060084661-A1 | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2006-04-20 | — | — | US | disclosed |
| EP-1357909-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2006-01-04 | — | — | EP | disclosed |
| US-20040132694-A1 | Il-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2004-07-08 | — | — | US | disclosed |
| EP-1357909-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002067919-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132694-A1 | Il-8 receptor antagonists | CXCL8, CCR8, TLR8 | HRH4 436/4885ERN1 3617/4885ALDH1A1 2352/4885 |
| US-20060084661-A1 | IL-8 receptor antagonists | CXCL8, CCR8, TLR8 | HRH4 436/4885ERN1 3617/4885ALDH1A1 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.