Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 12/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593317 | 0.72 | CA1 (0.33) | CA1LMNACYP3A4TSHRNFKB1 | |
| SCHEMBL6792625 | 0.71 | ABCC8 (0.44) | LMNACYP3A4TSHRABCC8KCNJ11 | |
| SCHEMBL6208560 | 0.71 | ABCC8 (0.38) | CA2ABCC8KCNJ11GRIA1GRIA2 | |
| SCHEMBL6798761 | 0.69 | ABCC8 (0.43) | CA2ABCC8KCNJ11GRIA1GRIA2 | |
| SCHEMBL8286612 | 0.69 | ABCC8 (0.50) | CA1LMNACYP3A4TSHRCA12 | |
| SCHEMBL6997132 | 0.69 | ABCC8 (0.43) | LMNACYP3A4TSHRABCC8KCNJ11 | |
| SCHEMBL6791814 | 0.67 | CA1 (0.47) | CA1LMNACYP3A4TSHRNFKB1 | |
| SCHEMBL7565061 | 0.66 | ABCC8 (0.43) | LMNACYP3A4TSHRABCC8KCNJ11 | |
| SCHEMBL4260154 | 0.66 | ABCC8 (0.46) | LMNACYP3A4TSHRABCC8KCNJ11 | |
| SCHEMBL2777400 | 0.64 | CA1 (0.58) | CA1LMNACYP3A4TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476668-B2 | Thiadiazine derivatives and use thereof as positive AMPA receptor modulators | LES LABORATOIRES SERVIER (FR) | 2009-01-13 | — | — | US | disclosed |
| US-20070004709-A1 | Thiadiazine derivatives and use thereof as positive ampa receptor modulators | THE UNIVERSITE DE LIEGE (BE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004709-A1 | Thiadiazine derivatives and use thereof as positive ampa receptor modulators | GRM1, GRM3, GABRA1 | CA1 1724/4885LMNA 4589/4885CYP3A4 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.