Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL97622 | 0.82 | KCNA3 (0.41) | ALDH1A1LMNAALOX15RECQLPPARA | |
| SCHEMBL13731916 | 0.82 | CA12 (0.44) | ALDH1A1CA1CA2CA12CA7 | |
| SCHEMBL3799734 | 0.79 | IDO1 (0.46) | ALDH1A1CYP2A6CA1CA2LMNA | |
| SCHEMBL12250930 | 0.77 | CA1 (0.52) | ALDH1A1CA1CA2CA12CA7 | |
| SCHEMBL11404883 | 0.77 | ALDH1A1 (0.46) | ALDH1A1CYP2A6CA1CA2CA12 | |
| SCHEMBL19168587 | 0.77 | ALDH1A1 (0.66) | ALDH1A1CYP2A6LMNATDP1PPARA | |
| SCHEMBL3164547 | 0.74 | TAAR1 (0.48) | ALDH1A1CYP2A6CA1CA2CA12 | |
| SCHEMBL6174994 | 0.74 | CA12 (0.48) | ALDH1A1CA1CA2CA12CA7 | |
| SCHEMBL21991543 | 0.72 | PPARA (0.57) | ALDH1A1CA1CA2PPARAMAPT | |
| SCHEMBL22548826 | 0.72 | ALDH1A1 (0.51) | ALDH1A1CA1CA2CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124819-A1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124819-A1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124819-A1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-14 | — | — | US | disclosed |
| EP-1466900-B1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | TAKAYAMA HIROAKI (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-20050131242-A1 | 2-substituted vitamin d derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1466900-A1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124819-A1 | 2-SUBSTITUTED VITAMIN D DERIVATIVES | VDR, CYP2R1, CYP24A1 | ALDH1A1 184/4885CYP2A6 132/4885CA1 4563/4885 |
| US-20050131242-A1 | 2-substituted vitamin d derivatives | VDR, CYP2R1, CYP24A1 | ALDH1A1 238/4885CYP2A6 102/4885CA1 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.