Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878894 | 0.90 | HSD11B1 (0.42) | TRPA1TRPV1RBP4PPARGHSD11B1 | |
| SCHEMBL3876034 | 0.86 | TRPV1 (0.44) | TRPA1TRPV1HSD11B1 | |
| SCHEMBL3878643 | 0.85 | TRPA1 (0.43) | TRPA1TRPV1RBP4HSD11B1GAA | |
| SCHEMBL3881354 | 0.84 | TRPV1 (0.48) | TRPV1HSD11B1 | |
| SCHEMBL13761373 | 0.84 | TRPV1 (0.45) | TRPV1HSD11B1 | |
| SCHEMBL13761395 | 0.84 | HSD11B1 (0.43) | TRPV1HSD11B1 | |
| SCHEMBL3880107 | 0.84 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL3887131 | 0.84 | TRPV1 (0.41) | TRPA1TRPV1RBP4HSD11B1 | |
| SCHEMBL3889392 | 0.81 | HSD11B1 (0.47) | TRPV1HSD11B1 | |
| SCHEMBL3879463 | 0.81 | HSD11B1 (0.42) | TRPA1TRPV1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |