Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388704 | 0.83 | OPRM1 (0.46) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388485 | 0.82 | OPRM1 (0.45) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL387210 | 0.81 | HRH3 (0.52) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL385080 | 0.79 | HRH3 (0.46) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL389846 | 0.79 | OPRM1 (0.51) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388503 | 0.78 | OPRM1 (0.54) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388127 | 0.78 | HRH3 (0.51) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388553 | 0.75 | OPRM1 (0.55) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL388111 | 0.75 | OPRM1 (0.53) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL390206 | 0.75 | HRH3 (0.55) | HRH3OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101638-B2 | 6-substituted nicotinamide derivatives as opioid receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |
| US-20090023785-A1 | 6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | PEDREGAL-TERCERO CONCEPCION | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023785-A1 | 6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | OPRM1, OPRK1, OPRD1 | HRH3 587/4885OPRM1 1/4885OPRD1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.