Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 5/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3875128 | 0.79 | F10 (0.46) | KCNH2F10HRH3PARP1PARP2 | |
| SCHEMBL3885138 | 0.79 | HTR4 (0.33) | HTR4METAP2F10HRH3NPY5R | |
| SCHEMBL10232790 | 0.77 | XPNPEP1 (0.36) | HTR4METAP2KCNH2HRH3ALDH1A1 | |
| SCHEMBL3879326 | 0.75 | ALDH1A1 (0.35) | HTR4F10HRH3ALDH1A1SMYD3 | |
| SCHEMBL24837283 | 0.74 | HTR4 (0.35) | HTR4METAP2KCNH2F10HRH3 | |
| Fumaric Acid SCHEMBL3873520 | 0.73 | F10 (0.42) | F10HRH3PARP1PARP2ALDH1A1 | |
| SCHEMBL14725150 | 0.73 | HRH3 (0.40) | HTR4KCNH2HRH3PARP1PARP2 | |
| SCHEMBL21942932 | 0.71 | HTR4 (0.45) | HTR4KCNH2F10HRH3ALDH1A1 | |
| SCHEMBL12026481 | 0.70 | HTR4 (0.47) | HTR4KCNH2F10HRH3ALDH1A1 | |
| SCHEMBL3872689 | 0.70 | F10 (0.33) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888567-B1 | HETEROARYL-CARBOXYLIC ACID (SULFAMOYL ALKYL) AMIDE - DERIVATIVES AS FACTOR XA INHIBITORS | SANOFI AVENTIS (FR) | 2009-12-16 | — | — | EP | claimed |