Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968295 | 0.99 | TLR7 (0.64) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL14516511 | 0.88 | TLR7 (0.52) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL3823102 | 0.88 | TLR7 (0.54) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL5370008 | 0.87 | TLR7 (0.60) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL4565227 | 0.86 | TLR7 (0.51) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL5358343 | 0.86 | TLR7 (0.59) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL20284100 | 0.85 | TLR7 (0.61) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL6280434 | 0.85 | TLR7 (0.51) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL483690 | 0.84 | TLR7 (0.50) | TLR7POLBLMNAHRH2ADRA1D | |
| SCHEMBL13956155 | 0.84 | TLR7 (0.56) | TLR7POLBLMNAHRH2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188111-B2 | Amide and carbamate derivatives of alkyl substituted N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyI]methanesulfonamides and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188111-B2 | Amide and carbamate derivatives of alkyl substituted N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyI]methanesulfonamides and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090176821-A1 | Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090176821-A1 | Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| EP-1924582-A4 | AMIDE AND CARBAMATE DERIVATIVES OF ALKYL SUBSTITUTED N-[4-(4-AMINO-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)BUTYL]METHANESULFONAMIDES AND METHODS | COLEY PHARM GROUP INC (US) | 2009-04-15 | — | — | EP | disclosed |
| CN-101300257-A | Amide and carbamate derivatives of alkyl substituted N- [ 4- (4-amino-1H-imidazo [4, 5-c ] quinolin-1-yl) butyl ] methanesulfonamides and methods | COLEY PHARM GROUP INC (US) | 2008-11-05 | — | — | CN | disclosed |
| CN-101300257-A | Amide and carbamate derivatives of alkyl substituted N- [ 4- (4-amino-1H-imidazo [4, 5-c ] quinolin-1-yl) butyl ] methanesulfonamides and methods | COLEY PHARM GROUP INC (US) | 2008-11-05 | — | — | CN | disclosed |
| EP-1924582-A2 | AMIDE AND CARBAMATE DERIVATIVES OF ALKYL SUBSTITUTED N-[4-(4-AMINO-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)BUTYL]METHANESULFONAMIDES AND METHODS | Coley Pharmaceutical Group, Inc. (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030777-A3 | AMIDE AND CARBAMATE DERIVATIVES OF ALKYL SUBSTITUTED N-[4-(4-AMINO-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)BUTYL]METHANESULFONAMIDES AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007030777-A2 | AMIDE AND CARBAMATE DERIVATIVES OF ALKYL SUBSTITUTED N-[4-(4-AMINO-1H-IMIDAZO[4,5-C]QUINOLIN-1-YL)BUTYL]METHANESULFONAMIDES AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176821-A1 | Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods | IFNG, CCL11, IL4 | TLR7 273/4885POLB 2759/4885LMNA 3624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.