Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879988 | 0.90 | GPR119 (0.41) | TBK1GPR119 | |
| SCHEMBL3888408 | 0.89 | IRAK4 (0.34) | CHRM4EGFRTBK1ERBB2 | |
| SCHEMBL3945087 | 0.85 | CHRM4 (0.36) | CHRM4EGFRERBB2 | |
| SCHEMBL3879322 | 0.81 | CHRM4 (0.33) | CHRM4TBK1 | |
| SCHEMBL3879481 | 0.81 | TBK1 (0.36) | TBK1 | |
| SCHEMBL5519256 | 0.81 | TBK1 (0.36) | TBK1 | |
| Hydrochloric Acid SCHEMBL3880946 | 0.81 | CHRM4 (0.32) | CHRM4TBK1 | |
| SCHEMBL3880872 | 0.80 | IRAK4 (0.42) | EGFRTBK1GPR119 | |
| SCHEMBL3881251 | 0.77 | SRC (0.32) | — | |
| SCHEMBL3887939 | 0.76 | SRC (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-B1 | QUINOLINE THIAZOLINONES WITH CDK-1 ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |