Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879481 | 1.00 | TBK1 (0.36) | TBK1PDE9AIKBKE | |
| SCHEMBL3879322 | 0.90 | CHRM4 (0.33) | TBK1 | |
| Hydrochloric Acid SCHEMBL3880946 | 0.89 | CHRM4 (0.32) | TBK1 | |
| SCHEMBL3880907 | 0.87 | TBK1 (0.35) | TBK1PDE9AIKBKE | |
| SCHEMBL3945087 | 0.86 | CHRM4 (0.36) | — | |
| SCHEMBL3879988 | 0.82 | GPR119 (0.41) | TBK1IKBKE | |
| SCHEMBL3887939 | 0.82 | SRC (0.33) | — | |
| SCHEMBL3880068 | 0.81 | SRC (0.34) | — | |
| SCHEMBL3886015 | 0.81 | CHRM4 (0.33) | TBK1 | |
| SCHEMBL3884763 | 0.81 | PDE9A (0.39) | TBK1PDE9AIKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-11 | — | — | EP | claimed |
| WO-2006002828-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | claimed |