Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493289 | 0.87 | OPRM1 (0.32) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3494038 | 0.82 | BACE1 (0.40) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3494036 | 0.82 | BACE1 (0.40) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3493024 | 0.80 | ALDH1A1 (0.35) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3493026 | 0.80 | ALDH1A1 (0.35) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3492106 | 0.74 | BACE1 (0.38) | BACE1BACE2 | |
| SCHEMBL3492102 | 0.74 | BACE1 (0.38) | BACE1BACE2 | |
| SCHEMBL765892 | 0.72 | BACE1 (0.37) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3892756 | 0.72 | BACE1 (0.37) | BACE1BACE2OPRL1OPRM1 | |
| SCHEMBL3491947 | 0.72 | BACE1 (0.37) | BACE1BACE2OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091328-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054698-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-05-08 | — | — | WO | disclosed |