Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13435143 | 0.87 | BACE1 (0.39) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL3494202 | 0.85 | BACE1 (0.34) | BACE1OPRM1OPRL1BACE2 | |
| SCHEMBL8244592 | 0.85 | BACE1 (0.43) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL3491947 | 0.85 | BACE1 (0.37) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL3892756 | 0.85 | BACE1 (0.37) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL764691 | 0.84 | ADORA3 (0.40) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL13359099 | 0.83 | OPRM1 (0.37) | BACE1OPRM1OPRL1BACE2OPRK1 | |
| SCHEMBL760030 | 0.83 | BACE1 (0.34) | BACE1OPRM1OPRL1BACE2 | |
| SCHEMBL755862 | 0.83 | BACE1 (0.34) | BACE1OPRM1OPRL1BACE2 | |
| SCHEMBL755429 | 0.83 | BACE1 (0.34) | BACE1OPRM1OPRL1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-B1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2007011810-A1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | disclosed |