Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.66 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL767254 | 0.93 | CHRNA7 (0.57) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| SCHEMBL391952 | 0.93 | CHRNA7 (0.66) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| Fumaric Acid SCHEMBL392434 | 0.91 | CHRNA7 (0.55) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| SCHEMBL12274238 | 0.91 | CHRNA7 (0.63) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| Fumaric Acid SCHEMBL767250 | 0.85 | CHRNA7 (0.48) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| Fumaric Acid SCHEMBL391501 | 0.84 | CHRNA7 (0.55) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| SCHEMBL1395946 | 0.83 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3HTR3A | |
| SCHEMBL1769897 | 0.83 | CHRNA7 (0.62) | CHRNA7CHRNB4CHRNA3NPC1RAB9A | |
| SCHEMBL1769835 | 0.82 | NPC1 (0.48) | CHRNA7NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL498835 | 0.82 | NPC1 (0.45) | CHRNA7CHRNB4CHRNA3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172353-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE | DANPET AB (SE) | 2012-07-05 | — | — | US | claimed |
| US-20110112078-A1 | NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2011-05-12 | — | — | US | claimed |
| EP-2288608-A1 | NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2011-03-02 | — | — | EP | claimed |
| US-7807667-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use | NEUROSEARCH A/S (DK) | 2010-10-05 | — | — | US | claimed |
| US-20100216780-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | DANPET AB (SE) | 2010-08-26 | — | — | US | claimed |
| EP-2032575-B1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVE AND ITS MEDICAL USE | NEUROSEARCH AS (DK) | 2010-04-07 | — | — | EP | claimed |
| WO-2009150138-A1 | NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-12-17 | — | — | WO | claimed |
| US-20090118266-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CANADIAN IMPERIAL BANK OF COMMERCE AS AGENT | 2009-05-07 | — | — | US | claimed |
| EP-2032575-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-03-11 | — | — | EP | claimed |
| EP-2032574-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-03-11 | — | — | EP | claimed |
| WO-2007138037-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-12-06 | — | — | WO | claimed |
| WO-2007138038-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-12-06 | — | — | WO | claimed |
| US-8372832-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use | NEUROSEARCH A/S (DK) | 2013-02-12 | — | — | US | disclosed |
| US-20120172353-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE | DANPET AB (SE) | 2012-07-05 | — | — | US | disclosed |
| US-8158619-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl compounds and their medical use | NEUROSEARCH A/S (DK) | 2012-04-17 | — | — | US | disclosed |
| US-8106042-B2 | 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives useful as modulator of nicotinic acetylcholine receptors | NEUROSEARCH A/S (DK) | 2012-01-31 | — | — | US | disclosed |
| EP-2032575-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-03-11 | — | — | EP | disclosed |
| EP-2032574-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138037-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007138038-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216780-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA6, CHRNA2 | CHRNA7 7/4885CHRNB4 12/4885CHRNA3 1/4885 |
| US-20090118266-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA2, CHRNA5 | CHRNA7 8/4885CHRNB4 10/4885CHRNA3 1/4885 |
| US-20110112078-A1 | NOVEL OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE | CHRNA3, CHRNA6, CHRNA7 | CHRNA7 3/4885CHRNB4 12/4885CHRNA3 1/4885 |
| US-20120172353-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL COMPOUNDS AND THEIR MEDICAL USE | CHRNA3, CHRNA6, CHRNA2 | CHRNA7 7/4885CHRNB4 12/4885CHRNA3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.