Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 10/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL392434 | 0.94 | CHRNA7 (0.55) | CHRNA7POLBNPC1CHRNB4CHRNA3 | |
| SCHEMBL767254 | 0.91 | CHRNA7 (0.57) | CHRNA7POLBNPC1CHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL391501 | 0.89 | CHRNA7 (0.55) | CHRNA7NPC1CHRNB4CHRNA3RAB9A | |
| SCHEMBL388683 | 0.85 | CHRNA7 (0.66) | CHRNA7POLBNPC1CHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL2113241 | 0.79 | CHRNA7 (0.65) | CHRNA7CHRNB4CHRNA3 | |
| SCHEMBL391952 | 0.78 | CHRNA7 (0.66) | CHRNA7NPC1CHRNB4CHRNA3RAB9A | |
| Fumaric Acid SCHEMBL5220969 | 0.78 | CHRNA7 (0.56) | CHRNA7CHRNB4CHRNA3HSD17B10SMN1; SMN2 | |
| Fumaric Acid SCHEMBL5218174 | 0.78 | CHRNA7 (0.65) | CHRNA7NPC1CHRNB4CHRNA3RAB9A | |
| Fumaric Acid SCHEMBL2111723 | 0.77 | CHRNA7 (0.64) | CHRNA7NPC1CHRNB4CHRNA3RAB9A | |
| Fumaric Acid SCHEMBL2112124 | 0.77 | CHRNA7 (0.55) | CHRNA7POLBNPC1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071469-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071469-A1 | NOVEL 1,4-DIAZA-BICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA10, CHRNA3, CHRNA6 | CHRNA7 5/4885POLB 2558/4885NPC1 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.