Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | METAP1 | P53582 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30702212 | 0.84 | MAPT (0.56) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL3948845 | 0.84 | MAPT (0.56) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2246351 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTACHELMNARAB9A | |
| SCHEMBL8370379 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2MEN1MAPTKMT2AAKR1C3 | |
| SCHEMBL5659127 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPTACHELMNA | |
| SCHEMBL5660492 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPTACHELMNA | |
| SCHEMBL1992671 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPTACHELMNA | |
| SCHEMBL23618751 | 0.75 | MAPT (0.70) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL8021509 | 0.75 | ACHE (0.54) | SMN1; SMN2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL5311960 | 0.73 | KMT2A (0.55) | SMN1; SMN2KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078010-A2 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008083367-A2 | POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |