Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 13/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839121 | 0.85 | CHEK1 (0.48) | AURKAKDRCHEK1 | |
| SCHEMBL3887524 | 0.84 | KDR (0.49) | AURKAKDRCHEK1 | |
| SCHEMBL3837181 | 0.80 | CHEK1 (0.56) | AURKAKDRCHEK1 | |
| Hydrochloric Acid SCHEMBL3874594 | 0.79 | CHEK1 (0.49) | AURKAKDRCHEK1 | |
| SCHEMBL3839022 | 0.79 | CHEK1 (0.63) | AURKAKDRCHEK1 | |
| SCHEMBL3839156 | 0.79 | CHEK1 (0.56) | AURKAKDRCHEK1 | |
| SCHEMBL3839118 | 0.78 | CHEK1 (0.49) | AURKAKDRCHEK1 | |
| SCHEMBL3046676 | 0.78 | CHEK1 (0.48) | AURKAKDRCHEK1 | |
| Hydrochloric Acid SCHEMBL3046615 | 0.76 | AURKA (0.68) | AURKAKDRCHEK1 | |
| Hydrochloric Acid SCHEMBL3841238 | 0.75 | CHEK1 (0.49) | AURKAKDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |