Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL237636 | 0.88 | HCAR2 (0.38) | HCAR2KMT2ALMNASLC6A3ADRB3 | |
| SCHEMBL610844 | 0.88 | MTNR1A (0.35) | HCAR2ALOX5EPHX2KMT2AMTNR1A | |
| SCHEMBL233923 | 0.86 | DDB1 (0.39) | KMT2A | |
| SCHEMBL3863963 | 0.83 | FFAR1 (0.40) | LMNA | |
| SCHEMBL3840890 | 0.83 | KMT2A (0.37) | ALOX5EPHX2KMT2AMTNR1AMTNR1B | |
| SCHEMBL3868117 | 0.82 | HTR2C (0.39) | ALOX5EPHX2KMT2AMTNR1AMTNR1B | |
| SCHEMBL3839542 | 0.81 | PTPN11 (0.41) | ALOX5EPHX2KMT2AMTNR1AMTNR1B | |
| SCHEMBL3839399 | 0.77 | ALOX5 (0.44) | ALOX5EPHX2MTNR1AMTNR1BCNR1 | |
| SCHEMBL28053008 | 0.76 | MTNR1A (0.51) | KMT2AMTNR1AMTNR1BLMNAALDH1A1 | |
| SCHEMBL27996046 | 0.75 | HPGD (0.51) | KMT2AMTNR1AMTNR1BLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |