Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069135 | 0.89 | MTNR1A (0.62) | MTNR1AMTNR1BCASRL3MBTL1AOC3 | |
| SCHEMBL3839542 | 0.86 | PTPN11 (0.41) | MTNR1AMTNR1BCASRFFAR1PTGES | |
| SCHEMBL27941337 | 0.86 | MTNR1A (0.44) | MTNR1AMTNR1BCASRFFAR1L3MBTL1 | |
| SCHEMBL3862302 | 0.85 | PTGES (0.49) | MTNR1AMTNR1BCASRFFAR1PTGES | |
| SCHEMBL3840890 | 0.81 | KMT2A (0.37) | MTNR1AMTNR1BCASRKMT2ALMNA | |
| SCHEMBL3839399 | 0.80 | ALOX5 (0.44) | MTNR1AMTNR1BCASR | |
| SCHEMBL16031499 | 0.79 | PTGES (0.45) | FFAR1PTGESLMNAHAO1GRM5 | |
| SCHEMBL16030517 | 0.79 | GRM5 (0.38) | MTNR1AMTNR1BPTGESMEN1KMT2A | |
| SCHEMBL3863963 | 0.77 | FFAR1 (0.40) | FFAR1LMNA | |
| SCHEMBL3859009 | 0.76 | ALOX5 (0.35) | MTNR1AMTNR1BPTGESALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541769-A | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | ACUCELA INC | 2016-05-04 | — | — | CN | disclosed |
| CN-103664637-B | Be used for the treatment of ophthalmic diseases and disorderly alkynyl phenyl derivative compounds | ACUCELA INC. (US) | 2016-02-03 | — | — | CN | disclosed |