Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922820 | 0.70 | SLC18A3 (0.40) | HSD11B1NPSR1ALDH1A1KDM4EMCOLN3 | |
| Diphenylether SCHEMBL2024590 | 0.70 | LTA4H (0.46) | HSD11B1CCR5 | |
| SCHEMBL3879514 | 0.70 | HSD11B1 (0.54) | HSD11B1DDB1CRBNNPSR1ALDH1A1 | |
| SCHEMBL2986964 | 0.70 | HSD11B1 (1.00) | HSD11B1ROCK2DDB1CRBNALDH1A1 | |
| SCHEMBL15677633 | 0.69 | MCHR1 (0.43) | ROCK2HDAC8HDAC6DDB1CRBN | |
| SCHEMBL13108447 | 0.69 | MEN1 (0.61) | HSD11B1NPSR1ALDH1A1SMN1; SMN2OPRK1 | |
| SCHEMBL15973833 | 0.68 | HSD11B1 (0.48) | HSD11B1NPSR1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7606593 | 0.68 | HDAC8 (0.67) | ROCK2HDAC8HDAC6DDB1CRBN | |
| SCHEMBL3878986 | 0.68 | HSD11B1 (0.74) | HSD11B1NPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL893008 | 0.67 | POLB (0.49) | HSD11B1NPSR1ALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | claimed |
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | disclosed |