Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997600 | 0.72 | PDPK1 (0.44) | HSD11B1DDB1CRBNALDH1A1 | |
| SCHEMBL6218393 | 0.72 | DDB1 (0.43) | DDB1CRBNALDH1A1HSD17B10MAPT | |
| SCHEMBL11066306 | 0.70 | SLC18A3 (0.40) | HSD11B1NPSR1ALDH1A1HSD17B10MCOLN3 | |
| SCHEMBL10857013 | 0.70 | HDAC1 (0.43) | DDB1CRBNALDH1A1L3MBTL1 | |
| SCHEMBL3887675 | 0.70 | HSD11B1 (0.54) | HSD11B1DDB1CRBNNPSR1ALDH1A1 | |
| SCHEMBL2986964 | 0.70 | HSD11B1 (1.00) | HSD11B1DDB1CRBNALDH1A1MCOLN3 | |
| SCHEMBL3878986 | 0.68 | HSD11B1 (0.74) | HSD11B1NPSR1ALDH1A1TP53HTT | |
| SCHEMBL2946543 | 0.67 | ALDH1A1 (0.54) | DDB1CRBNALDH1A1HSD17B10SLC18A3 | |
| SCHEMBL809509 | 0.67 | ALDH1A1 (0.54) | DDB1CRBNALDH1A1HSD17B10SLC18A3 | |
| SCHEMBL13674416 | 0.67 | HSD11B1 (0.60) | HSD11B1ALDH1A1HSD17B10HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | claimed |