Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.59 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.59 |
| ▸ | DAO | P14920 | 1/20 | 0.58 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1092502 | 0.84 | KDM4E (0.62) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL3651263 | 0.84 | NOD2 (0.65) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL6988991 | 0.83 | NOD2 (0.71) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL3259707 | 0.83 | NOD2 (0.71) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL4791517 | 0.83 | NOD2 (0.60) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL4740839 | 0.83 | NOD2 (0.60) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL1585615 | 0.83 | NOD2 (0.60) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL7884242 | 0.82 | DAO (0.64) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL28665557 | 0.82 | NOD2 (0.70) | NOD2NOD1MEN1KMT2AKDM4E | |
| SCHEMBL28669136 | 0.82 | NOD2 (0.70) | NOD2NOD1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408761-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2197842-A1 | 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009032124-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009032116-A1 | 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |