Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | STS | P08842 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755220 | 1.00 | MAPT (0.68) | MAPTALDH1A1CYP3A4HPGDLMNA | |
| SCHEMBL27840727 | 0.91 | STS (0.64) | MAPTALDH1A1CYP3A4HPGDLMNA | |
| SCHEMBL29275355 | 0.90 | BCHE (0.75) | MAPTALDH1A1CYP3A4LMNACYP1B1 | |
| SCHEMBL25199779 | 0.89 | MAOB (0.68) | MAPTALDH1A1CYP1B1BCHEMAOB | |
| SCHEMBL13434627 | 0.89 | MAOB (0.68) | MAPTALDH1A1CYP1B1BCHEMAOB | |
| SCHEMBL25190545 | 0.89 | MAOB (0.68) | MAPTALDH1A1CYP1B1BCHEMAOB | |
| SCHEMBL29275331 | 0.88 | STS (0.57) | MAPTALDH1A1CYP3A4HPGDLMNA | |
| SCHEMBL27775812 | 0.88 | MAOB (0.58) | MAPTALDH1A1CYP3A4HPGDLMNA | |
| SCHEMBL27840728 | 0.88 | MAOB (0.58) | MAPTALDH1A1CYP3A4HPGDLMNA | |
| SCHEMBL28574144 | 0.85 | ALDH1A1 (0.65) | ALDH1A1HPGDLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102199113-A | Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds | SNU R&DB FOUNDATION | 2011-09-28 | — | — | CN | claimed |
| EP-2099440-A1 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS | Seoul National University Industry Foundation (KR) | 2009-09-16 | — | — | EP | claimed |
| WO-2008069608-A1 | METHOD FOR SCREENING ANTI-CANCER COMPOUNDS INHIBITING FUNCTION OF TM4SF5 AND ANTI-CANCER COMPOSITION CONTAINING CHALCONE COMPOUNDS | SEOUL NATIONALUNIVERSITY INDUSTRY FOUNDATION (KR) | 2008-06-12 | — | — | WO | claimed |
| CN-101528210-B | Method for screening anticancer compound inhibiting TM4SF5 function and anticancer composition containing chalcone compound | SEOUL NAT UNIV IND FOUNDATION | 2012-05-23 | — | — | CN | disclosed |
| CN-102199113-A | Method for screening anti-cancer compounds inhibiting function of TM4SF5 and anti-cancer composition containing chalcone compounds | SNU R&DB FOUNDATION | 2011-09-28 | — | — | CN | disclosed |