Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 1/20 | 0.77 |
| ▸ | STAT3 | P40763 | 1/20 | 0.75 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.71 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.63 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.63 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3890737 | 1.00 | ALDH1A1 (0.77) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3894542 | 0.87 | POLB (0.74) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL12990045 | 0.87 | POLB (0.74) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3894547 | 0.87 | POLB (0.74) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122832 | 0.87 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122845 | 0.87 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL3122838 | 0.87 | POLB (1.00) | ALDH1A1LMNAPOLBMAPTRAB9A | |
| SCHEMBL16496688 | 0.86 | STAT3 (1.00) | STAT3PSMB8INSRIGF1RPTPN12 | |
| SCHEMBL1430728 | 0.86 | STAT3 (1.00) | STAT3PSMB8INSRIGF1RPTPN12 | |
| SCHEMBL3897032 | 0.85 | POLB (0.78) | ALDH1A1LMNAPOLBMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | claimed |
| WO-2005041951-A2 | RHODANINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | claimed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | UBQLN1, UBQLN2, UBE2G2 | ALDH1A1 1828/4885LMNA 3753/4885POLB 2008/4885 |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RBX1, ITCH, UBQLN1 | ALDH1A1 3199/4885LMNA 4343/4885POLB 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.