Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.53 |
| ▸ | CNR1 | P21554 | 3/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894629 | 0.80 | CNR2 (0.57) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL4876419 | 0.79 | CNR2 (0.57) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL4884688 | 0.77 | CNR2 (0.55) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL4882979 | 0.75 | CNR2 (0.53) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL4876418 | 0.75 | CNR2 (0.53) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL17865785 | 0.75 | ADORA2A (0.59) | CNR2CNR1NAMPTADORA2AALDH1A1 | |
| SCHEMBL3893570 | 0.74 | MAPT (0.57) | CNR2CNR1ALDH1A1HPGDLMNA | |
| SCHEMBL22040703 | 0.72 | HDAC1 (0.60) | CNR2CNR1NAMPTADORA2AHDAC3 | |
| SCHEMBL29836705 | 0.72 | L3MBTL1 (0.67) | CNR2CNR1ALDH1A1HPGDLMNA | |
| SCHEMBL18652182 | 0.71 | HDAC6 (0.55) | CNR2CNR1NAMPTADORA2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572790-B2 | Biphenyl carboxylic amide p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | MAPK1, MAPKAPK2, MAPK7 | CNR2 989/4885CNR1 932/4885NAMPT 1971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.