Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | BCR | P11274 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1130935 | 0.91 | CCNT1 (0.45) | ABL1BCRCCNT1CDK9USP30 | |
| SCHEMBL1130998 | 0.91 | CCNT1 (0.45) | ABL1BCRCCNT1CDK9USP30 | |
| SCHEMBL1131364 | 0.81 | SRC (0.42) | SMN1; SMN2USP30SRCPOLB | |
| SCHEMBL31563787 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2GPR119POLB | |
| SCHEMBL1131590 | 0.81 | GPR119 (0.40) | GPR119 | |
| SCHEMBL3903362 | 0.81 | GPR119 (0.40) | GPR119 | |
| SCHEMBL1068114 | 0.78 | HSD17B10 (0.43) | ABL1BCRSMN1; SMN2GPR119SRC | |
| SCHEMBL1068111 | 0.78 | HSD17B10 (0.43) | ABL1BCRSMN1; SMN2GPR119SRC | |
| SCHEMBL29255152 | 0.75 | LTA4H (0.49) | ABL1BCR | |
| SCHEMBL10255074 | 0.73 | ALDH1A1 (0.41) | CCNT1CDK9SMN1; SMN2USP30HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501422-B2 | Prolinamide-tetrazole derivatives as NK3 receptor antagonists | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |