Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610349 | 0.84 | NOTUM (0.46) | SMN1; SMN2P2RX7LMNAHPGDNPC1 | |
| Hydrochloric Acid SCHEMBL6437878 | 0.84 | KMT2A (0.44) | MAPK1SMN1; SMN2P2RX7LMNAPOLB | |
| SCHEMBL7066002 | 0.84 | ABCB1 (0.50) | CHRNA7MAPTSMN1; SMN2P2RX7LMNA | |
| SCHEMBL7294542 | 0.83 | MAPT (0.66) | MAPTSMN1; SMN2LMNAPOLBHPGD | |
| SCHEMBL13097411 | 0.79 | GRM5 (0.56) | SMN1; SMN2HSD17B10LMNAHPGDTSHR | |
| SCHEMBL5569349 | 0.78 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL22502298 | 0.78 | PDE4A (0.49) | CHRNA7MAPTMAPK1HTR2AHTR2C | |
| SCHEMBL22502300 | 0.78 | PDE4A (0.49) | CHRNA7MAPTMAPK1HTR2AHTR2C | |
| SCHEMBL11082062 | 0.77 | SMPD1 (0.57) | MAPTSMN1; SMN2HSD17B10LMNAHPGD | |
| SCHEMBL6414662 | 0.77 | HTR2C (0.72) | MAPK1HTR2AHTR2CHTR2BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| US-7495016-B2 | Pyrrolidones with anti-HIV activity | IRM LLC (BM) | 2009-02-24 | — | — | US | disclosed |
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2008-10-16 | — | — | US | disclosed |
| US-20040157859-A1 | Pyrrolidones with anti-HIV activity | IRM LLC, A DELAWARE LLC (BM) | 2004-08-12 | — | — | US | disclosed |
| WO-2004037784-A2 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | PREP, DHPS, PDCD11 | CHRNA7 4780/4885MAPT 1836/4885MAPK1 2282/4885 |
| US-20040157859-A1 | Pyrrolidones with anti-HIV activity | PREP, DHPS, PDCD11 | CHRNA7 4780/4885MAPT 1836/4885MAPK1 2282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.