Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697582 | 0.91 | MMP13 (0.54) | SMN1; SMN2HTTLMNAMMP13RAB9A | |
| SCHEMBL13097411 | 0.86 | GRM5 (0.56) | SMN1; SMN2HTTLMNAALDH1A1RAB9A | |
| SCHEMBL5535678 | 0.84 | MAOB (0.56) | SMN1; SMN2ALDH1A1RAB9ANPC1KCNH2 | |
| SCHEMBL28570818 | 0.82 | MAOB (0.56) | SMN1; SMN2HTTLMNAMMP13KCNH2 | |
| SCHEMBL13097167 | 0.82 | GRM5 (0.54) | ALDH1A1RAB9ANPC1KCNH2MCHR1 | |
| SCHEMBL13097418 | 0.81 | CACNA2D1 (0.54) | ALDH1A1RAB9ANPC1KCNH2MCHR1 | |
| SCHEMBL3364915 | 0.80 | MAOB (0.56) | SMN1; SMN2ALDH1A1RAB9ANPC1KCNH2 | |
| SCHEMBL19086546 | 0.80 | F10 (0.54) | MMP13ALDH1A1MCHR1GAAMAPT | |
| Hydrochloric Acid SCHEMBL6437878 | 0.79 | KMT2A (0.44) | SMN1; SMN2HTTLMNAALDH1A1RAB9A | |
| SCHEMBL5610349 | 0.79 | NOTUM (0.46) | SMN1; SMN2HTTLMNAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112851561-A | NR6A1 protein receptor inhibitor and preparation and application thereof | 南京艾美斐生物医药科技有限公司 | 2021-05-28 | — | — | CN | disclosed |
| US-7456210-B2 | Benzyloxy derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456210-B2 | Benzyloxy derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-11-25 | — | — | US | disclosed |
| CN-100383118-C | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-23 | — | — | CN | disclosed |
| US-7235581-B2 | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMAN-LA ROCHE INC. (US) | 2007-06-26 | — | — | US | disclosed |
| CN-1681779-A | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | CN | disclosed |
| EP-1542971-A1 | 4-PYRROLIDINO-PHENYL-BENZYL ETHER DERIVATIVES | F. Hoffmann-La Roche Ltd. (CH) | 2005-06-22 | — | — | EP | disclosed |
| US-20040097578-A1 | 4-Pyrrolidino-phenyl-benzyl ether derivatives | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2004-05-20 | — | — | US | disclosed |
| WO-2004026826-A1 | 4-PYRROLIDINO-PHENYL-BENZYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097578-A1 | 4-Pyrrolidino-phenyl-benzyl ether derivatives | MAOB, MAOA, COMT | SMN1; SMN2 913/4885HTT 316/4885LMNA 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.