Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.42 |
| ▸ | PDE2A | O00408 | 4/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 2/20 | 0.40 |
| ▸ | PDE6A | P16499 | 2/20 | 0.40 |
| ▸ | PDE6G | P18545 | 2/20 | 0.40 |
| ▸ | PDE6B | P35913 | 2/20 | 0.40 |
| ▸ | PDE6C | P51160 | 2/20 | 0.40 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24165355 | 1.00 | MAOA (0.53) | MAOAALDH1A1CYP11B1CYP11B2PDE10A | |
| SCHEMBL1271246 | 0.88 | MAOA (0.59) | MAOAALDH1A1PDE10APDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL9623496 | 0.86 | MAOA (0.61) | MAOAALDH1A1PDE10APDGFRBPDGFRA | |
| SCHEMBL8292355 | 0.82 | CLK1 (0.46) | CYP11B1CYP11B2 | |
| SCHEMBL26374138 | 0.81 | MAOA (0.38) | MAOACYP11B1CYP11B2 | |
| SCHEMBL3204828 | 0.80 | MAOA (0.51) | MAOAALDH1A1CYP3A4POLB | |
| SCHEMBL16431842 | 0.80 | IKBKB (0.55) | MAOAALDH1A1CYP11B1CYP11B2PDGFRB | |
| SCHEMBL22929106 | 0.80 | MAOA (0.51) | MAOAALDH1A1PDE10APDGFRBPDGFRA | |
| SCHEMBL29380244 | 0.80 | IKBKB (0.55) | MAOAALDH1A1CYP11B1CYP11B2PDGFRB | |
| SCHEMBL6768743 | 0.80 | MAOA (0.51) | MAOAALDH1A1PDE10APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| US-20090312313-A1 | COMPOUND HAVING TGFBETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-12-17 | — | — | US | disclosed |
| US-7560558-B2 | Compound having TGFβ inhibitory activity and medicinal composition containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-07-14 | — | — | US | disclosed |
| US-20060111375-A1 | Compound having tgfß inhibitory activity and medicinal composition containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-05-25 | — | — | US | disclosed |
| EP-1548008-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND MEDICINAL COMPOSITION CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2005-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111375-A1 | Compound having tgfß inhibitory activity and medicinal composition containing the same | TGFB1, TGFBR1, TGFBR2 | MAOA 1672/4885ALDH1A1 1257/4885CYP11B1 590/4885 |
| US-20090312313-A1 | COMPOUND HAVING TGFBETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | TGFB1, TGFBR1, TGFBR2 | MAOA 1536/4885ALDH1A1 1845/4885CYP11B1 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.