Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB2 | P47870 | 5/20 | 0.80 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.80 |
| ▸ | ALB | P02768 | 2/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 1/20 | 0.80 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.80 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.80 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.80 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | HTR2B | P41595 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | TSPO | P30536 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309142 | 0.92 | GABRB2 (0.78) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL80516 | 0.89 | GABRB2 (1.00) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL5606185 | 0.89 | GABRB2 (1.00) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL28035123 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL28577249 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL15169819 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2064875 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2065026 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL5766080 | 0.88 | GABRB2 (0.97) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL2064510 | 0.87 | GABRB2 (0.91) | GABRB2GABRA1ALBOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809627-B1 | SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT | MALLINCKRODT INC (US) | 2009-12-09 | — | — | EP | claimed |
| EP-1809627-B1 | SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT | MALLINCKRODT INC (US) | 2009-12-09 | — | — | EP | disclosed |
| US-7498439-B2 | Synthesis of heteroaryl acetamides from reaction mixtures having reduced water content | MALLINCKRODT INC. (US) | 2009-03-03 | — | — | US | disclosed |
| EP-1575952-B1 | SYNTHESIS OF HETEROARYL ACETAMIDES | MALLINCKRODT INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-7385056-B2 | Synthesis of heteroaryl acetamides | MALLINCKRODT INC. (US) | 2008-06-10 | — | — | US | disclosed |
| US-20070213537-A1 | Synthesis Of Heteroaryl Acetamides From Reaction Mixtures Having Reduced Water Content | MALLINCKRODT INC. | 2007-09-13 | — | — | US | disclosed |
| EP-1809627-A1 | SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT | MALLINCKRODT, INC. (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060025588-A1 | Synthesis of heteroaryl acetamides | MALLINCKRODT INC. | 2006-02-02 | — | — | US | disclosed |
| WO-2006007289-A1 | SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT | MALLINCKRODT INC. (US) | 2006-01-19 | — | — | WO | disclosed |
| WO-2006007289-A1 | SYNTHESIS OF HETEROARYL ACETAMIDES FROM REACTION MIXTURES HAVING REDUCED WATER CONTENT | MALLINCKRODT INC. (US) | 2006-01-19 | — | — | WO | disclosed |
| EP-1575952-A1 | SYNTHESIS OF HETEROARYL ACETAMIDES | MALLINCKRODT INC. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058758-A1 | SYNTHESIS OF HETEROARYL ACETAMIDES | MALLINCKRODT INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025588-A1 | Synthesis of heteroaryl acetamides | HTR2A, SQSTM1, CYP2A6 | GABRB2 245/4885GABRA1 76/4885ALB 2082/4885 |
| US-20070213537-A1 | Synthesis Of Heteroaryl Acetamides From Reaction Mixtures Having Reduced Water Content | SQSTM1, CYP3A43, HTR2A | GABRB2 869/4885GABRA1 229/4885ALB 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.