Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.67 |
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP14 | P50281 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904150 | 0.89 | ADAMTS4 (0.59) | ADAMTS4MMP2MMP14GAALMNA | |
| SCHEMBL12684680 | 0.80 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL12247612 | 0.80 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL1658546 | 0.80 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP14MMP13MMP7 | |
| SCHEMBL20124798 | 0.79 | ADAMTS4 (0.86) | ADAMTS4MMP2MMP14MAPTMMP13 | |
| SCHEMBL3896601 | 0.78 | ADAMTS4 (0.62) | ADAMTS4MMP2MMP14GAALMNA | |
| SCHEMBL1655209 | 0.75 | ADAMTS4 (0.78) | ADAMTS4MMP2MMP14MAPTCASP3 | |
| SCHEMBL3904143 | 0.73 | ADAMTS4 (0.55) | ADAMTS4MMP2MMP14GAALMNA | |
| SCHEMBL7798915 | 0.73 | ALDH1A1 (0.54) | MMP2GAALMNAMMP13MMP7 | |
| SCHEMBL7402462 | 0.72 | GRIA4 (0.53) | ADAMTS4MMP2GAAMMP13MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689380-A4 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | WYETH CORP (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1689380-A2 | METHOD FOR TREATING ADAMTS-5-ASSOCIATED DISEASE | Wyeth (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1689716-A1 | BIARYL SULFONAMIDES AND METHODS FOR USING SAME | Wyeth (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005060456-A2 | METHOD FOR TREATING ADAMTS-5-ASSOCIATE DISEASE | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061459-A1 | BIARYL SULFONAMIDES AND METHODS FOR USING SAME | WYETH (US) | 2005-07-07 | — | — | WO | disclosed |