Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644131 | 0.89 | CDK5 (0.72) | HPGDCDK5CDK5R1L3MBTL1KMT2A | |
| SCHEMBL12644135 | 0.88 | CDK5 (0.56) | HPGDTP53MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL13551001 | 0.84 | LMNA (0.52) | HPGDTP53MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL13464844 | 0.84 | SMN1; SMN2 (0.60) | HPGDTP53MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19776852 | 0.84 | TP53 (0.60) | HPGDTP53MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL23131497 | 0.84 | CDK5 (0.62) | HPGDTP53MAPTSMN1; SMN2RXFP1 | |
| SCHEMBL12644136 | 0.83 | MAPT (0.53) | HPGDTP53MAPTSMN1; SMN2CDK5 | |
| SCHEMBL12644334 | 0.83 | HPGD (0.56) | HPGDSMN1; SMN2CDK5CDK5R1ALDH1A1 | |
| SCHEMBL12644134 | 0.82 | LMNA (0.51) | HPGDTP53MAPTSMN1; SMN2CDK5 | |
| SCHEMBL12644132 | 0.82 | TP53 (0.55) | HPGDTP53MAPTSMN1; SMN2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | HPGD 3243/4885TP53 1019/4885MAPT 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.