SCHEMBL12644136

SCHEMBL12644136

O=C1Nc2cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)ccc2Sc2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.53
SMN1; SMN2 Q16637 5/20 0.53
HTT P42858 3/20 0.53
ALDH1A1 P00352 1/20 0.53
TSHR P16473 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
HPGD P15428 1/20 0.51
HSP90AA1 P07900 1/20 0.51
CDK5 Q00535 1/20 0.49
CDK5R1 Q15078 1/20 0.49
POLB P06746 2/20 0.48
KDM4E B2RXH2 1/20 0.48
TP53 P04637 3/20 0.48
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13551001 0.91 LMNA (0.52) MAPTSMN1; SMN2ALDH1A1TSHRHPGD
SCHEMBL12644135 0.91 CDK5 (0.56) MAPTSMN1; SMN2ALDH1A1TSHRHPGD
SCHEMBL13464844 0.85 SMN1; SMN2 (0.60) MAPTSMN1; SMN2HTTTSHRHPGD
SCHEMBL19776852 0.85 TP53 (0.60) MAPTSMN1; SMN2ALDH1A1HPGDCDK5
SCHEMBL3897334 0.83 HPGD (0.60) MAPTSMN1; SMN2ALDH1A1HPGDCDK5
SCHEMBL12587775 0.83 MAPT (0.53) MAPTSMN1; SMN2HTTALDH1A1HPGD
SCHEMBL12644134 0.81 LMNA (0.51) MAPTSMN1; SMN2HTTALDH1A1TSHR
SCHEMBL24715672 0.80 SMN1; SMN2 (0.53) MAPTSMN1; SMN2HTTALDH1A1TSHR
SCHEMBL12644132 0.79 TP53 (0.55) MAPTSMN1; SMN2HTTALDH1A1TSHR
SCHEMBL12644131 0.76 CDK5 (0.72) HPGDCDK5CDK5R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346797-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-11-02 US disclosed
US-20210121476-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-04-29 US disclosed
US-20210085679-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-03-25 US disclosed
US-10881669-B2 Inhibitors of the plasmodial surface anion channel as antimalarials THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2021-01-05 US disclosed
US-10869865-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) 2020-12-22 US disclosed
US-20190183889-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) 2019-06-20 US disclosed
US-10265313-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2019-04-23 US disclosed
US-9974796-B2 Inhibitors of the plasmodial surface anion channel as antimalarials THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2018-05-22 US disclosed
US-20180015086-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) 2018-01-18 US disclosed
US-9808458-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2017-11-07 US disclosed
US-20160324866-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS US HEALTH (US) 2016-11-10 US disclosed
US-9394316-B2 Inhibitors of the plasmodial surface anion channel as antimalarials THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-07-19 US disclosed
US-20160193207-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2016-07-07 US disclosed
EP-2313100-B1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS US HEALTH (US) 2016-05-11 EP disclosed
US-9320786-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-04-26 US disclosed
US-20140088082-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The U.S.A., as represented by the Secretary, Department of Health and Human Services. (US) 2014-03-27 US disclosed
US-20140079736-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2014-03-20 US disclosed
WO-2012142125-A2 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2012-10-18 WO disclosed
US-20110144086-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS The United States of America, as represented by the Secretary, Dept of Health and Human Service (US) 2011-06-16 US disclosed
WO-2010011537-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2010-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230346797-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885SMN1; SMN2 2079/4885HTT 3829/4885
US-20140088082-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885SMN1; SMN2 2079/4885HTT 3829/4885
US-10265313-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885SMN1; SMN2 4569/4885HTT 3492/4885
US-10869865-B2 Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885SMN1; SMN2 4569/4885HTT 3492/4885
US-20110144086-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, SLC9A1, CATSPER1 MAPT 2404/4885SMN1; SMN2 2040/4885HTT 3883/4885
US-10881669-B2 Inhibitors of the plasmodial surface anion channel as antimalarials SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885SMN1; SMN2 2079/4885HTT 3829/4885
US-20180015086-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3432/4885SMN1; SMN2 4553/4885HTT 3496/4885
US-20210121476-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885SMN1; SMN2 2079/4885HTT 3829/4885
US-20140079736-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3435/4885SMN1; SMN2 4364/4885HTT 3383/4885
US-20210085679-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885SMN1; SMN2 4569/4885HTT 3492/4885
US-20160193207-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885SMN1; SMN2 4569/4885HTT 3492/4885
US-20190183889-A1 PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA CLIC1, SLC47A2, SLC47A1 MAPT 3506/4885SMN1; SMN2 4569/4885HTT 3492/4885
US-20160324866-A1 INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS SLC8B1, CATSPER1, SLC9A1 MAPT 2404/4885SMN1; SMN2 2079/4885HTT 3829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.