Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12644135 | 0.92 | CDK5 (0.56) | SMN1; SMN2TP53MAPTRXFP1LMNA | |
| SCHEMBL19776852 | 0.90 | TP53 (0.60) | SMN1; SMN2TP53MAPTRXFP1LMNA | |
| SCHEMBL13551001 | 0.90 | LMNA (0.52) | SMN1; SMN2TP53MAPTRXFP1LMNA | |
| SCHEMBL12587775 | 0.88 | MAPT (0.53) | SMN1; SMN2TP53MAPTLMNAKDM4E | |
| SCHEMBL12644136 | 0.85 | MAPT (0.53) | SMN1; SMN2TP53MAPTLMNAKDM4E | |
| SCHEMBL3897334 | 0.84 | HPGD (0.60) | SMN1; SMN2TP53MAPTRXFP1LMNA | |
| SCHEMBL12644132 | 0.80 | TP53 (0.55) | SMN1; SMN2TP53MAPTLMNAKDM4E | |
| SCHEMBL12644134 | 0.80 | LMNA (0.51) | SMN1; SMN2TP53MAPTLMNATSHR | |
| SCHEMBL23131497 | 0.77 | CDK5 (0.62) | SMN1; SMN2TP53MAPTRXFP1LMNA | |
| SCHEMBL12644131 | 0.77 | CDK5 (0.72) | HPGDMEN1KMT2ACDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346797-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-11-02 | — | — | US | disclosed |
| EP-2696873-B1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | US HEALTH (US) | 2022-08-03 | — | — | EP | disclosed |
| US-20210121476-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-04-29 | — | — | US | disclosed |
| US-20210085679-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-03-25 | — | — | US | disclosed |
| US-10881669-B2 | Inhibitors of the plasmodial surface anion channel as antimalarials | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2021-01-05 | — | — | US | disclosed |
| US-10869865-B2 | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190183889-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2019-06-20 | — | — | US | disclosed |
| US-10265313-B2 | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2019-04-23 | — | — | US | disclosed |
| US-9974796-B2 | Inhibitors of the plasmodial surface anion channel as antimalarials | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-22 | — | — | US | disclosed |
| US-20180015086-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2018-01-18 | — | — | US | disclosed |
| US-9808458-B2 | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-11-07 | — | — | US | disclosed |
| US-20160324866-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | US HEALTH (US) | 2016-11-10 | — | — | US | disclosed |
| US-9394316-B2 | Inhibitors of the plasmodial surface anion channel as antimalarials | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2016-07-19 | — | — | US | disclosed |
| US-20160193207-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2016-07-07 | — | — | US | disclosed |
| EP-2313100-B1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | US HEALTH (US) | 2016-05-11 | — | — | EP | disclosed |
| US-20140088082-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | The U.S.A., as represented by the Secretary, Department of Health and Human Services. (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012142125-A2 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230346797-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | SLC8B1, CATSPER1, SLC9A1 | SMN1; SMN2 2079/4885TP53 4525/4885MAPT 2404/4885 |
| US-20140088082-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | SLC8B1, CATSPER1, SLC9A1 | SMN1; SMN2 2079/4885TP53 4525/4885MAPT 2404/4885 |
| US-10265313-B2 | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4569/4885TP53 3589/4885MAPT 3506/4885 |
| US-10869865-B2 | Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4569/4885TP53 3589/4885MAPT 3506/4885 |
| US-10881669-B2 | Inhibitors of the plasmodial surface anion channel as antimalarials | SLC8B1, CATSPER1, SLC9A1 | SMN1; SMN2 2079/4885TP53 4525/4885MAPT 2404/4885 |
| US-20180015086-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4553/4885TP53 3614/4885MAPT 3432/4885 |
| US-20210121476-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | SLC8B1, CATSPER1, SLC9A1 | SMN1; SMN2 2079/4885TP53 4525/4885MAPT 2404/4885 |
| US-20210085679-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4569/4885TP53 3589/4885MAPT 3506/4885 |
| US-20160193207-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4569/4885TP53 3589/4885MAPT 3506/4885 |
| US-20190183889-A1 | PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA | CLIC1, SLC47A2, SLC47A1 | SMN1; SMN2 4569/4885TP53 3589/4885MAPT 3506/4885 |
| US-20160324866-A1 | INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS | SLC8B1, CATSPER1, SLC9A1 | SMN1; SMN2 2079/4885TP53 4525/4885MAPT 2404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.