Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722247 | 0.82 | HTR6 (0.48) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL5922702 | 0.82 | HTR6 (0.48) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL6733104 | 0.80 | HTR6 (0.58) | HTR6L3MBTL1MEN1KMT2AHTT | |
| SCHEMBL1898211 | 0.80 | HTR6 (0.56) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL1306928 | 0.75 | HTR6 (0.54) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL29408218 | 0.75 | MEN1 (0.60) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL1892821 | 0.75 | HTR6 (0.54) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL2573218 | 0.75 | MEN1 (0.60) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL17049296 | 0.75 | HTR6 (0.51) | HTR6L3MBTL1MEN1KMT2ASLC1A3 | |
| SCHEMBL30669307 | 0.74 | HTR6 (0.50) | HTR6L3MBTL1MEN1KMT2ASLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654251-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20060205740-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-09-14 | — | — | US | disclosed |
| EP-1654251-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016914-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205740-A1 | Chemical compounds | ERBB2, ERBB4, ERBB3 | HTR6 2297/4885L3MBTL1 4480/4885MEN1 2540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.