Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828613 | 0.93 | HRH4 (0.34) | HRH4HTR3A | |
| SCHEMBL1586586 | 0.85 | KDM1A (0.31) | HTR2CHTR2A | |
| SCHEMBL6788944 | 0.81 | — | — | |
| Quinoxaline SCHEMBL7485007 | 0.77 | MEN1 (0.35) | HTR2C | |
| SCHEMBL1650443 | 0.76 | HRH4 (0.37) | HTR2CHRH4HTR3A | |
| SCHEMBL571897 | 0.75 | — | — | |
| SCHEMBL14741159 | 0.75 | — | — | |
| SCHEMBL32689488 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL9391692 | 0.73 | KDM1A (0.31) | — | |
| SCHEMBL27752202 | 0.73 | KDM1A (0.44) | HTR2CHRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476679-B2 | Octahydroisoquinoline compounds as opioid receptor modulators | RESEARCH TRIANGLE INSTITUTE (US) | 2009-01-13 | — | — | US | disclosed |
| EP-1906962-A2 | OCTAHYDROISOQUINOLINE COMPOUNDS AS OPIOID RECEPTOR MODULATORS | RESEARCH TRIANGLE INSTITUTE (US) | 2008-04-09 | — | — | EP | disclosed |
| US-20070027182-A1 | Octahydroisoquinoline compounds as opioid receptor modulators | RESEARCH TRIANGLE INSTITUTE (US) | 2007-02-01 | — | — | US | disclosed |
| WO-2007014263-A2 | OCTAHYDROISOQUINOLINE COMPOUNDS AS OPIOID RECEPTOR MODULATORS | RESEARCH TRIANGLE INSTITUTE (US) | 2007-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027182-A1 | Octahydroisoquinoline compounds as opioid receptor modulators | OPRL1, OPRM1, OPRK1 | HTR2C 25/4885PDE4B 1846/4885CHRM3 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.