Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TET3 | O43151 | 1/20 | 0.56 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.56 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.56 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.56 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2794291 | 0.91 | OPRL1 (0.64) | CCR3SIGMAR1KMT2ATET3FBXL19 | |
| SCHEMBL27679327 | 0.90 | CCR3 (0.66) | CCR3SIGMAR1KMT2ADRD4DRD2 | |
| Hydrochloric Acid SCHEMBL2793069 | 0.90 | POLB (0.65) | CCR3SIGMAR1KMT2ATET3FBXL19 | |
| Hydrochloric Acid SCHEMBL3904000 | 0.89 | CCR3 (0.64) | CCR3SIGMAR1KMT2ADRD4DRD2 | |
| SCHEMBL31223141 | 0.87 | ALDH1A1 (0.56) | CCR3SIGMAR1KMT2AOPRL1POLB | |
| SCHEMBL8349645 | 0.87 | CCR3 (0.61) | CCR3SIGMAR1KMT2ADRD4DRD2 | |
| SCHEMBL8349651 | 0.85 | CCR3 (0.60) | CCR3SIGMAR1KMT2ADRD4DRD2 | |
| SCHEMBL26459082 | 0.83 | CCR3 (0.50) | CCR3KMT2AOPRL1POLBCYP2D6 | |
| SCHEMBL16263190 | 0.82 | OPRL1 (0.56) | KMT2AOPRL1POLBCYP2D6CHRM2 | |
| SCHEMBL12121940 | 0.82 | KMT2A (0.58) | KMT2ATET3FBXL19CXXC5KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006084-B | 4-arylmorpholin-3-one derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS | 2010-09-08 | — | — | CN | disclosed |
| US-7521449-B2 | 4-arylmorpholin-3-one derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-04-21 | — | — | US | disclosed |
| CN-101006084-A | 4-arylmorpholin-3-one derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS (FR) | 2007-07-25 | — | — | CN | disclosed |
| US-20070142349-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142349-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | ADRB3, ADRA2C, OPRK1 | CCR3 196/4885SIGMAR1 53/4885KMT2A 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.