Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032190 | 0.86 | KDM4E (0.39) | KDM4EALDH1A1KMT2AGAAHCAR3 | |
| SCHEMBL1313407 | 0.75 | MAOA (0.49) | ALDH1A1KMT2ALMNAMAPTTXNRD1 | |
| SCHEMBL30021226 | 0.74 | TXNRD1 (0.43) | ALDH1A1KMT2ALMNAMAPTTXNRD1 | |
| SCHEMBL2069040 | 0.74 | TXNRD1 (0.43) | ALDH1A1KMT2ALMNAMAPTTXNRD1 | |
| SCHEMBL1030746 | 0.73 | TXNRD1 (0.36) | KDM4EALDH1A1KMT2AGAAMAPT | |
| SCHEMBL3885163 | 0.73 | PIN1 (0.38) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL3887047 | 0.71 | MEN1 (0.38) | KDM4EALDH1A1KMT2ALMNAMAOA | |
| SCHEMBL27772658 | 0.71 | TXNRD1 (0.41) | KDM4EALDH1A1MAPTTXNRD1GSR | |
| SCHEMBL3889926 | 0.70 | MAPT (0.39) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL23273999 | 0.70 | PIN1 (0.54) | KMT2ALMNATXNRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013179-A1 | ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007118859-A1 | ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2007-10-25 | — | — | WO | disclosed |