Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390047 | 1.00 | ACACB (0.43) | ACACBCXCR3PDE10AHRH3GRIN2D | |
| SCHEMBL389972 | 1.00 | ACACB (0.43) | ACACBCXCR3PDE10AHRH3GRIN2D | |
| SCHEMBL21812435 | 0.82 | ADRA1A (0.47) | ACACBPDE10AHRH3GRIN2DGRIN3B | |
| SCHEMBL6573621 | 0.81 | HRH3 (0.59) | ACACBCXCR3HRH3GPR119 | |
| SCHEMBL3178582 | 0.80 | NPY5R (0.40) | ACACBHRH3GPR119 | |
| SCHEMBL28424965 | 0.79 | GPR119 (0.52) | HRH3GPR119 | |
| SCHEMBL15224314 | 0.77 | HRH3 (0.52) | ACACBPDE10AHRH3AKR1C3 | |
| SCHEMBL21812344 | 0.77 | SMO (0.50) | PDE10A | |
| SCHEMBL28715870 | 0.77 | AKR1C3 (0.49) | CXCR3PDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL31144105 | 0.77 | AKR1C3 (0.49) | CXCR3PDE10AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101764-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |