Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.41 |
| ▸ | TESK2 | Q96S53 | 2/20 | 0.41 |
| ▸ | TESK1 | Q15569 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12991170 | 0.80 | MEN1 (0.48) | LIMK1PIK3CACYP3A4KDRPIK3CG | |
| SCHEMBL3904608 | 0.78 | LIMK1 (0.45) | LIMK1PIK3CACYP3A4KDRPIK3CG | |
| SCHEMBL3905457 | 0.77 | LIMK1 (0.46) | LIMK1PIK3CACYP3A4PIK3CGLIMK2 | |
| SCHEMBL925427 | 0.76 | PIK3CG (0.56) | ATAD2PIK3CAPIK3CGPIK3CDPIK3R1 | |
| SCHEMBL5840422 | 0.75 | KDR (0.72) | LIMK1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL25682571 | 0.75 | KDR (0.44) | CYP3A4KDRGSTO1CCNE1CDK2 | |
| SCHEMBL17632040 | 0.72 | ABL1 (0.62) | LIMK1KDRPIK3CGGSTO1CCNE1 | |
| SCHEMBL13158536 | 0.72 | CCNE1 (0.48) | PIK3CACYP3A4CLK1CCNE1CDK2 | |
| SCHEMBL25683131 | 0.71 | POLB (0.51) | LIMK1KDRGSTO1CCNE1CDK2 | |
| SCHEMBL9285608 | 0.71 | ALDH1A1 (0.51) | LIMK1PIK3CAKDRPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484452-A | Thiazole derivatives and their use as anti-tumour agents | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| EP-2016075-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | AstraZeneca AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007129044-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | MTOR, RPTOR, JAK2 | ATAD2 2025/4885LIMK1 709/4885PIK3CA 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.