SCHEMBL3901288

SCHEMBL3901288

[C-]#[N+]C(C)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.52
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
HIF1A Q16665 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
LMNA P02545 2/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 1/20 0.41
CYP2A6 P11509 1/20 0.40
SLC6A2 P23975 3/20 0.39
SLC6A3 Q01959 3/20 0.39
SLC6A4 P31645 3/20 0.39
BRD4 O60885 1/20 0.39
FFAR2 O15552 1/20 0.38
CYP19A1 P11511 3/20 0.38
IDO1 P14902 2/20 0.38
TDO2 P48775 2/20 0.38
AOC3 Q16853 1/20 0.35
AKT1 P31749 1/20 0.35
HDAC4 P56524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11858783 0.78 ADRB2 (0.50) ADRB2TSHRMAPK1HIF1ATDP1
SCHEMBL197810 0.75 ADRB2 (0.65) ADRB2TSHRMAPK1HIF1ATDP1
SCHEMBL2560254 0.75 IDO1 (0.39) LMNASLC6A2SLC6A3SLC6A4IDO1
SCHEMBL12053468 0.75 MEN1 (0.40) ADRB2MAPK1HIF1ATDP1TP53
SCHEMBL2554184 0.75 CYP2A6 (0.40) MAPK1HPGDCYP2A6
SCHEMBL377591 0.74 TAAR1 (0.42) TSHRHIF1ALMNA
SCHEMBL2406731 0.74 TAAR1 (0.42) TSHRHIF1ALMNA
SCHEMBL450918 0.74 TAAR1 (0.42) TSHRHIF1ALMNA
SCHEMBL29953215 0.73 PNMT (0.41) ADRB2TSHRHPGDSLC6A2SLC6A3
SCHEMBL12204384 0.73 ADRB2 (0.45) ADRB2TSHRMAPK1HIF1ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
WO-2009145721-A1 ISOINDOLINE DERIVATIVES COMPRISING PHENYL GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed
WO-2009145718-A1 ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS ASTRAZENECA AB (SE) 2009-12-03 WO disclosed