Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | CA9 | Q16790 | 7/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | FAAH | O00519 | 2/20 | 0.59 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901529 | 1.00 | AURKA (0.72) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL11331666 | 0.91 | MEN1 (0.79) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL11331663 | 0.91 | MEN1 (0.79) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL12013235 | 0.91 | MEN1 (0.79) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL17309290 | 0.91 | MEN1 (0.79) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL3889647 | 0.89 | FAAH (0.76) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL3889652 | 0.89 | FAAH (0.76) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL17302242 | 0.87 | ALDH1A1 (0.67) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL13576508 | 0.85 | MEN1 (0.74) | AURKALMNATDP1MEN1ALDH1A1 | |
| SCHEMBL11324184 | 0.85 | MEN1 (0.74) | AURKALMNATDP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252940-B2 | 5-substituted-2-imino-thiazolidinone compounds and their use as inhibitors of bacterial infection | UNIVERSITY OF WASHINGTON (US) | 2012-08-28 | — | — | US | disclosed |
| WO-2009137133-A2 | 5-SUBSTITUTED-2-IMINO-THIAZOLIDINONE COMPOUNDS AND THEIR USE AS INHIBITORS OF BACTERIAL INFECTION | UNIVERSITY OF WASHINGTON (US) | 2009-11-12 | — | — | WO | disclosed |