Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.50 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3906098 | 0.88 | OPRL1 (0.56) | OPRM1OPRL1TACR1CNR2MTOR | |
| SCHEMBL3282870 | 0.78 | HDAC1 (0.44) | OPRM1OPRL1SLC6A9PNMTCNR2 | |
| SCHEMBL3903167 | 0.76 | OPRM1 (0.44) | OPRM1OPRL1TACR1CNR2 | |
| SCHEMBL3910532 | 0.74 | CASR (0.44) | OPRM1OPRL1TACR1SLC6A9CNR2 | |
| SCHEMBL3914023 | 0.74 | OPRM1 (0.41) | OPRM1OPRL1TACR1CNR2 | |
| SCHEMBL3905074 | 0.74 | CASR (0.53) | OPRM1OPRL1TACR1SLC6A9ACP3 | |
| SCHEMBL3914167 | 0.74 | PNMT (0.59) | PNMTACP3 | |
| SCHEMBL3904574 | 0.71 | MTNR1A (0.59) | BCHE | |
| SCHEMBL3905381 | 0.71 | CASR (0.45) | OPRL1TACR1 | |
| SCHEMBL3911825 | 0.71 | CNR1 (0.50) | OPRM1TACR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | claimed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | claimed |
| EP-2018364-A1 | THERAPEUTIC FLUOROETHYL UREAS | Allergan, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007137029-A1 | THERAPEUTIC FLUOROETHYL UREAS | ALLERGAN, INC. (US) | 2007-11-29 | — | — | WO | disclosed |