Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN12 | Q05209 | 1/20 | 0.66 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.66 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | DUSP22 | Q9NRW4 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | CFTR | P13569 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904180 | 1.00 | PTPN12 (0.66) | PTPN12PTPN22MAP3K5KEAP1NFE2L2 | |
| SCHEMBL29554158 | 0.92 | LCK (0.68) | PTPN12PTPN22MAP3K5DUSP22LCK | |
| SCHEMBL3896603 | 0.92 | LCK (0.68) | PTPN12PTPN22MAP3K5DUSP22LCK | |
| SCHEMBL3896597 | 0.92 | LCK (0.68) | PTPN12PTPN22MAP3K5DUSP22LCK | |
| SCHEMBL3896586 | 0.90 | PTPN12 (0.67) | PTPN12PTPN22MAP3K5STAT3DUSP22 | |
| SCHEMBL3896590 | 0.90 | PTPN12 (0.67) | PTPN12PTPN22MAP3K5STAT3DUSP22 | |
| SCHEMBL46216 | 0.89 | PTPN12 (0.77) | PTPN12PTPN22MAP3K5STAT3DUSP22 | |
| SCHEMBL6742617 | 0.89 | PTPN12 (0.77) | PTPN12PTPN22MAP3K5STAT3DUSP22 | |
| SCHEMBL29901264 | 0.87 | MEN1 (0.65) | PTPN12PTPN22MAP3K5LCKMEN1 | |
| SCHEMBL6784553 | 0.86 | PTPN12 (0.69) | PTPN12PTPN22MAP3K5STAT3DUSP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | claimed |
| US-7566732-B2 | Rhodanine compositions for use as antiviral agents | RIGEL PHARMACEUTICALS, INC. (US) | 2009-07-28 | — | — | US | disclosed |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276520-A1 | Rhodanine derivatives and pharmaceutical compositions containing them | UBQLN1, UBQLN2, UBE2G2 | PTPN12 3967/4885PTPN22 3961/4885MAP3K5 1092/4885 |
| US-20090137644-A1 | RHODANINE COMPOSITIONS FOR USE AS ANTIVIRAL AGENTS | RBX1, ITCH, UBQLN1 | PTPN12 3188/4885PTPN22 3667/4885MAP3K5 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.