Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3907807 | 1.00 | MMP2 (0.48) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL3904754 | 0.83 | MMP2 (0.51) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL2888169 | 0.81 | PSEN1 (0.52) | MMP2MMP9LMNAALDH1A1CYP1A2 | |
| SCHEMBL2888168 | 0.81 | PSEN1 (0.52) | MMP2MMP9LMNAALDH1A1CYP1A2 | |
| SCHEMBL3187445 | 0.78 | MMP2 (0.54) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL3906847 | 0.76 | PSEN1 (0.46) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL3904719 | 0.76 | PSEN1 (0.46) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL3904762 | 0.74 | MMP2 (0.50) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL3906115 | 0.74 | MMP2 (0.50) | MMP2MMP1MMP3MMP7MMP9 | |
| SCHEMBL10076123 | 0.73 | MMP2 (0.50) | MMP2MMP1MMP3MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221711-A1 | TRIFLUOROMETHYL-CONTAINING PHENYLSULFONAMIDE BETA AMYLOID INHIBITORS | WYETH (US) | 2009-09-03 | — | — | US | disclosed |
| US-7550629-B2 | 4-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]benzenesulfonamide; 4-cyano-N-(3,3,3-trifluoro-1-hydroxymethyl-2-trifluoromethyl-propyl)-benzenesulfonamide; Alzheimer's Disease, amyloid angiopathy, systemic amyloidosis, mild cognitive impairment and Down's syndrome | WYETH (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-7476762-B2 | Methods for preparing sulfonamide compounds | WYETH (US) | 2009-01-13 | — | — | US | disclosed |
| US-7476762-B2 | Methods for preparing sulfonamide compounds | WYETH (US) | 2009-01-13 | — | — | US | disclosed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249722-A1 | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | WYETH (US) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221711-A1 | TRIFLUOROMETHYL-CONTAINING PHENYLSULFONAMIDE BETA AMYLOID INHIBITORS | APP, PSEN1, BACE1 | MMP2 1636/4885MMP1 298/4885MMP3 1594/4885 |
| US-20070249722-A1 | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors | APP, PSEN1, BACE1 | MMP2 1636/4885MMP1 298/4885MMP3 1594/4885 |
| US-20070249723-A1 | Methods for preparing sulfonamide compounds | PNISR, RRM1, MRPS27 | MMP2 4403/4885MMP1 4650/4885MMP3 3238/4885 |
| US-20090082591-A1 | METHODS FOR PREPARING SULFONAMIDE COMPOUNDS | PNISR, RRM1, MRPS27 | MMP2 4403/4885MMP1 4650/4885MMP3 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.